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Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected

Lari C Young1, Mollie P Roediger, Greg Grandits

  • 1Center for Integrative Medicine, Wake Forest Baptist Health, Winston Salem, NC, USA.

Biomarkers in Medicine
|November 18, 2014
PubMed

Insights

In people with HIV, higher inflammation and clotting markers were linked to poorer cardiac autonomic function (CAF) at one point in time. However, these markers did not predict future CAF decline.

Area of Science:

  • Cardiology
  • Immunology
  • Infectious Diseases

Background:

  • Cardiac autonomic function (CAF) is crucial for cardiovascular health.
  • Inflammatory and coagulation biomarkers are implicated in cardiovascular disease.
  • HIV infection is associated with accelerated cardiovascular complications.

Purpose of the Study:

  • To investigate the association between inflammatory biomarkers (IL-6, hsCRP) and coagulation markers (D-dimer) with CAF in individuals with HIV.
  • To assess both cross-sectional and longitudinal relationships.

Main Methods:

  • Analysis of 4073 HIV-infected participants from the Strategies for Management of Antiretroviral Therapy (SMARTT) study.
  • Measurement of heart rate variability (HRV) parameters: SDNN and rMSSD.
  • Cross-sectional and longitudinal assessment of biomarker associations with HRV.

Main Results:

  • Cross-sectional analysis showed significant inverse associations between IL-6, hsCRP, D-dimer and HRV measures (SDNN, rMSSD).
  • Higher biomarker levels correlated with lower CAF.
  • Longitudinal analysis did not reveal a significant association between baseline biomarkers and changes in CAF over time.

Conclusions:

  • Higher inflammatory and coagulation biomarker levels are associated with reduced CAF in HIV-infected individuals at a single time point.
  • Baseline biomarker levels do not predict the decline in CAF over time, despite observed deterioration.
  • Further research is needed to understand the long-term impact of these biomarkers on CAF in HIV.
Abstract

Keywords:
HIVIL-6biomarkerscardiac autonomic functioncoagulationd-dimerheart rate variabilityhigh-sensitivity C-reactive proteininflammation

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