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Updated: Apr 20, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Reactive oxygen species and autophagy modulation in non-marine drugs and marine drugs

Ammad Ahmad Farooqi1, Sundas Fayyaz2, Ming-Feng Hou3

  • 1Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan. ammadfarooqi@rlmclahore.com.

Marine Drugs
|November 18, 2014
PubMed

Insights

This review explores how targeting reactive oxygen species (ROS) with drugs can fight cancer. It examines how these drugs induce cancer cell death via apoptosis and autophagy, highlighting marine and non-marine compounds.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Translational research faces challenges in developing drugs targeting reactive oxygen species (ROS) in cancer.
  • Numerous non-marine and marine drugs show potential in suppressing cancer progression via ROS-mediated cell death.

Purpose of the Study:

  • To review oxidative stress-based cancer therapy strategies.
  • To connect ROS modulation with apoptosis and autophagy regulation.
  • To explore the mechanisms of autophagy modulators in cancer treatment.

Main Methods:

  • Literature review of non-marine and marine drugs.
  • Analysis of ROS-mediated cell death pathways.
  • Examination of apoptosis and autophagy modulation in cancer.

Main Results:

  • Oxidative stress-based therapy is a viable strategy for cancer treatment.
  • ROS modulation influences both apoptosis and autophagy.
  • Autophagy inhibitors and inducers from various drug sources show therapeutic potential.

Conclusions:

  • Targeting ROS pathways offers a promising avenue for novel cancer therapeutics.
  • Autophagy modulation presents a key mechanism for drug development in oncology.
  • Marine and non-marine drugs provide a rich source for developing ROS-targeting cancer therapies.

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