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Not all parasites are protective.

Derek M McKay1

  • 1Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Gastrointestinal Research Group and Inflammation Research Network, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Parasite Immunology
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Helminth parasites can manipulate host immunity, potentially treating inflammatory diseases like diabetes and multiple sclerosis. However, some helminth infections may worsen existing immune conditions, requiring careful consideration for helminth therapy.

Keywords:
diseaseimmune modulationinflammation

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Area of Science:

  • Immunology
  • Parasitology
  • Infectious Diseases

Background:

  • Endoparasites must evade sophisticated host immune responses.
  • Helminths can modulate host immunity through molecular and cellular mechanisms.
  • Helminth infections in rodent models show potential for ameliorating inflammatory diseases.

Purpose of the Study:

  • To review the dual role of helminth infections in modulating host immunity.
  • To discuss the potential benefits and risks of helminth therapy for inflammatory diseases.
  • To highlight caveats for the therapeutic use of helminths.

Main Methods:

  • Literature review of helminth-host immune interactions.
  • Analysis of studies on helminth infection and experimental inflammatory diseases.
  • Case examples of helminth-induced exacerbation of immunopathologies.

Main Results:

  • Helminths can suppress or skew immune cell activity.
  • Infection with helminths can ameliorate experimental diabetes, inflammatory bowel disease, and multiple sclerosis.
  • Certain helminth infections can exacerbate existing immunopathologies.

Conclusions:

  • Helminth infections present a complex immunomodulatory profile.
  • While helminth therapy shows promise for inflammatory diseases, potential adverse effects must be considered.
  • Further research is needed to understand and manage the risks associated with helminth therapy.