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Updated: Jan 11, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Capacitating epistasis--detection and role in the genetic architecture of complex traits
Mats E Pettersson1, Orjan Carlborg
1Division of Computational Genetics, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7078, SE-750 07, Uppsala, Sweden.
Abstract:
Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.
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