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Related Concept Videos

Ureters01:22

Ureters

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The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
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Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Recent advances in ureteral tissue engineering.

Paul K J D de Jonge1, Vasileios Simaioforidis, Paul J Geutjes

  • 1Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands, paul.dejonge@radboudumc.nl.

Current Urology Reports
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Tissue engineering offers a promising alternative for reconstructing long ureteral defects, addressing limitations of current graft tissues. This review evaluates recent advancements in cell sources, implantation strategies, and biomaterials for ureteral regeneration.

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Area of Science:

  • Regenerative Medicine
  • Urology
  • Biomaterials Science

Background:

  • Reconstructing long ureteral defects typically requires graft tissue and complex surgeries.
  • Current methods face challenges including complication risks, graft failure, and tissue scarcity.
  • Tissue engineering presents a potential alternative but remains under-investigated.

Purpose of the Study:

  • To review and evaluate recent advancements in ureteral tissue engineering.
  • To focus on key components: cell sources, implantation strategies, and biomaterials.
  • To highlight the potential of tissue engineering for ureteral defect reconstruction.

Main Methods:

  • Systematic review of recent literature on ureteral tissue engineering.
  • Analysis of studies focusing on cell sources (e.g., stem cells, urothelial cells).
  • Evaluation of various implantation techniques and biomaterial scaffolds used in ureteral regeneration.

Main Results:

  • Identification of promising cell sources and biomaterials for ureteral tissue engineering.
  • Assessment of different surgical and implantation strategies for enhanced graft integration.
  • Synthesis of current data on the efficacy and limitations of engineered ureteral constructs.

Conclusions:

  • Ureteral tissue engineering shows significant potential for treating long ureteral defects.
  • Further research into optimal cell sources, biomaterials, and implantation methods is crucial.
  • Tissue engineering may overcome the limitations associated with traditional graft-based reconstruction.