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Updated: Apr 20, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Circular RNAs: diversity of form and function.

Erika Lasda¹, Roy Parker²

¹Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA.

RNA (New York, N.Y.)

|November 19, 2014

Summary

Circular RNAs (ribonucleic acids) are diverse molecules found in biological systems. This review covers their unique biogenesis, metabolism, and diverse functions, including roles in gene regulation and replication.

Keywords:

backsplicing circRNA circular RNA intermediates intron nonlinear splicing

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Identification of Circular RNAs using RNA Sequencing

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Published on: November 14, 2019

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Circular RNAs (circRNAs) represent a diverse class of RNA molecules with unique structures and functions.
Their biogenesis involves mechanisms like direct ligation, RNA processing intermediates, and backsplicing.
circRNAs possess distinct properties such as stability against exonucleases and potential for genomic information rearrangement.

Purpose of the Study:

To provide a comprehensive review of circular RNAs.
To elucidate the various mechanisms of circRNA biogenesis and metabolism.
To explore the known and potential functions of circRNAs in biological systems.

Main Methods:

Literature review of existing research on circular RNAs.
Analysis of studies detailing circRNA formation pathways.
Synthesis of data on circRNA properties and functional roles.

Main Results:

Circular RNAs are generated through multiple distinct pathways, including backsplicing.
They exhibit unique characteristics like resistance to degradation and ability to influence gene expression.
Identified functions include roles as miRNA sponges, transcriptional regulators, and intermediates in replication.

Conclusions:

Circular RNAs are prevalent and functionally significant molecules in biology.
Understanding circRNA biogenesis and function is crucial for advancing RNA biology.
Further research into circRNAs promises new insights into gene regulation and disease.