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Causality relationships between coagulation factors in type 2 diabetes mellitus: path analysis approach
Mohammad Reza Dayer1, Maysam Mard-Soltani2, Mohammad Saaid Dayer3
11. Assistant Professor, Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, Iran. mrdayer@scu.ac.ir.
Insights
Type 2 diabetes patients exhibit a hypercoagulable state, increasing vascular risks. Specific coagulation factors like Factor II (FII) are differently induced in diabetics compared to healthy individuals, impacting myocardial complication prognosis.
Area of Science:
- Cardiovascular research
- Hematology
- Endocrinology
Background:
- Type 2 diabetes mellitus (T2DM) patients are highly susceptible to vascular abnormalities and myocardial disease.
- A hypercoagulable state is implicated in the molecular events leading to these complications.
- Lack of consensus exists regarding the definition and initiating factors of the hypercoagulable state in T2DM.
Purpose of the Study:
- To investigate the interrelations between coagulation factors and pathogenic events in T2DM.
- To identify the initiating factors of the hypercoagulable state in diabetic and healthy individuals.
- To elucidate the role of coagulation factor interactions in myocardial complication prognosis.
Main Methods:
- Path analysis was employed to study interactions between coagulation factors and other related factors.
- Coagulation factors were experimentally determined in 40 healthy and 40 T2DM subjects.
- Multivariate regression analysis and path diagrams were utilized for data analysis using SPSS and AMOS software.
Main Results:
- Factor II (FII) was identified as the primary cause of the hypercoagulable state.
- In healthy individuals, FII is induced by Factor X (FX) and Factor VIII (FVIII).
- In diabetic patients, FII induction involves FX, Factor XI (FXI), Factor V (FV), and von Willebrand Factor (VWF) cofactors.
Conclusions:
- The relationship between coagulation factors is complex, with significant differences observed in T2DM.
- Specific cofactor involvement in FII induction varies between diabetic and healthy populations.
- Understanding these intricate relationships is crucial for determining the prognosis of myocardial complications in T2DM.
Background:
Type 2 diabetic mellitus patients are amongst the most susceptible groups to vascular abnormalities, which predominantly lead to myocardial disease. The hypercoagulable state has been widely studied by researchers as being the major suspicious mechanism facilitating the consecutive chain of molecular events leading to these complications. However, there is no consensus on the definition of the hypercoagulable state with respect to coagulation quantities, their interrelations and basic factor(s) initiating this pathogenic event, by which the prognosis of myocardial complications could be determined.
Methods:
Path analysis was used to study the interactions between coagulation factors as well as other factors beyond coagulation factors in relation with pathogenic events in both diabetics and healthy subjects. In the present work, coagulation factors of 40 healthy and 40 type 2 diabetics were determined experimentally. The data were then analyzed using SPSS and AMOS software. Multivariate regression analysis was done to draw path diagrams.
Results:
Our results show that FII, as the main cause for hypercoagulable state, is directly induced by FX and FVIII in normal individuals and by FX, FXI, FV and VWF cofactors in diabetic patients.
Conclusion:
In general, our findings showed complicated relationship between coagulation factors and their effects either separately or combined.
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