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Galectins as therapeutic targets for hematological malignancies: a hopeful sweetness
Camilo Pena1, Leonardo Mirandola1, Jose A Figueroa1
11 Department of Internal Medicine at the Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 2 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 3 Kiromic LLC, TX, USA ; 4 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 5 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 6 Humanitas Clinical and Research Center, Milan, Italy.
Abstract:
Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.
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