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Updated: Apr 20, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Bevacizumab maintenance in metastatic colorectal cancer: How long?
Alfonso De Stefano1, Roberto Moretto1, Chiara Alessandra Cella1
1Alfonso De Stefano, Roberto Moretto, Chiara Alessandra Cella, Francesco Jacopo Romano, Lucia Raimondo, Giovanni Fiore, Francesca Di Pietro, Sabino De Placido, Chiara Carlomagno, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
Abstract:
The management of patients with non-progressive metastatic colorectal cancer after six months of treatment has not yet been codified. The most relevant concerns are the effectiveness of maintenance vs discontinuation, and the tolerability of prolonged treatment. Here we report the case of a 72-year-old man affected by colorectal cancer with lung metastases who achieved a complete response after receiving capecitabine, oxaliplatin and bevacizumab for six months, and bevacizumab alone for six months. Bevacizumab was continued as maintenance regimen for more than three years. It was discontinued because of an arthroplasty. Fifty-eight months after beginning first-line treatment, the patient remains free from relapse. Adverse effects were minimal and easily controlled.
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