Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New approaches to vaccine development.

B R Bloom1

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.

Reviews of Infectious Diseases
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monoclonal antibodies against mycobacterial antigens.

Immunology today·2014
Same author

Mutually dependent secretion of proteins required for mycobacterial virulence.

Proceedings of the National Academy of Sciences of the United States of America·2005
Same author

Chips, infections, and national security.

Science (New York, N.Y.)·2001
Same author

Immunology. Chip shots--will functional genomics get functional?

Science (New York, N.Y.)·2001
Same author

Genetics and developing countries.

BMJ (Clinical research ed.)·2001
Same author

Induction of direct antimicrobial activity through mammalian toll-like receptors.

Science (New York, N.Y.)·2001

Developing new mycobacterial vaccines involves identifying virulence factors and using them to create live attenuated vaccines or combining protective antigens into multivaccine vehicles for tuberculosis prevention.

Area of Science:

  • Vaccinology
  • Microbiology
  • Immunology

Background:

  • Current vaccine development for enteric diseases offers insights into rational design for mycobacterial vaccines.
  • Understanding mycobacterial pathogenesis is crucial for identifying targets for vaccine intervention.

Purpose of the Study:

  • To survey current strategies for developing vaccines against enteric diseases.
  • To illuminate rational design approaches for mycobacterial vaccines, particularly for tuberculosis.

Main Methods:

  • Identifying virulence factors and employing transposon-mediated gene inactivation to create mutants.
  • Introducing protective antigens into live vaccine vectors to create multivaccine vehicles.

Main Results:

Related Experiment Videos

  • Virulence factor identification and gene inactivation provide insights into protective antigens and pathogenesis.
  • Genetic modification of virulence factors can inform the development of live attenuated vaccines.
  • Individual protective antigens can be incorporated into multivalent vaccine platforms.

    • Conclusions:

    • Strategies used for enteric disease vaccines can be adapted for rational mycobacterial vaccine design.
    • Both gene deletion/modification of virulence factors and antigen-based vector approaches are promising for improved tuberculosis vaccines.