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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

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Comparing HbA1c, fasting and 2-h plasma glucose for screening for abnormal glucose regulation in patients undergoing

Jun-Sing Wang, I-Te Lee, Wen-Jane Lee

    Clinical Chemistry and Laboratory Medicine
    |November 19, 2014
    PubMed

    Insights

    Undiagnosed abnormal glucose regulation is highly prevalent in patients undergoing coronary angiography. Glycated hemoglobin (HbA1c) shows strong performance for screening, potentially serving as an alternative to oral glucose tolerance tests (OGTT).

    Area of Science:

    • Cardiology
    • Endocrinology
    • Clinical Diagnostics

    Background:

    • Coronary angiography (CAG) patients often have undiagnosed abnormal glucose regulation (AGR), including diabetes and prediabetes.
    • Screening for AGR is crucial for cardiovascular risk management.
    • Current screening methods have limitations in this patient population.

    Purpose of the Study:

    • To determine the prevalence of undiagnosed AGR in patients undergoing CAG.
    • To compare the effectiveness of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and 2-hour plasma glucose (2hPG) in screening for AGR.
    • To evaluate HbA1c and oral glucose tolerance test (OGTT) as combined screening tools.

    Main Methods:

    • Adult patients without known diabetes undergoing CAG were enrolled.
    • Glucose regulation status was assessed using HbA1c and OGTT post-discharge.
    • Receiver operating characteristic (ROC) analysis evaluated the performance of FPG, 2hPG, and HbA1c for AGR detection.

    Main Results:

    • The study included 689 subjects.
    • AGR prevalence was 19.9% diabetes and 41.7% prediabetes by OGTT.
    • Using HbA1c alongside OGTT revealed higher prevalence: 28.0% diabetes and 60.4% prediabetes.
    • HbA1c demonstrated superior diagnostic performance compared to FPG and 2hPG for detecting both diabetes and AGR.

    Conclusions:

    • A very high prevalence of undiagnosed AGR exists in patients undergoing CAG.
    • HbA1c is a reliable and effective screening tool for AGR in this population.
    • HbA1c can be considered an alternative to OGTT for AGR screening in patients undergoing CAG.
    Abstract

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