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Antiadhesion agents against Gram-positive pathogens.

Stella Cascioferro1, Maria Grazia Cusimano, Domenico Schillaci

  • 1Department of Biological, Chemical & Pharmaceutical Science & Technology (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, Palermo, Italy.

Future Microbiology
|November 19, 2014
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Summary

This review explores antivirulence compounds targeting Gram-positive bacterial adhesion. These novel agents offer potential alternatives or complements to antibiotics for combating pathogens.

Keywords:
Gram-positive pathogensantiadhesion agentsantivirulence drugs

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Gram-positive bacterial pathogenesis relies on adhesion to host tissues.
  • Bacterial adhesins mediate interactions with host ligands, crucial for infection establishment.
  • Conventional antibiotics face increasing resistance, necessitating alternative therapeutic strategies.

Purpose of the Study:

  • To review antivirulence compounds targeting Gram-positive bacterial adhesins.
  • To assess the therapeutic potential of these compounds as alternatives or complements to antibiotics.
  • To discuss the advantages, disadvantages, and future perspectives of this antimicrobial development strategy.

Main Methods:

  • Literature review of antivirulence compounds targeting Gram-positive adhesins.
  • Identification of specific molecular targets, including sortase A and bacterial surface proteins.
  • Analysis of compounds such as sortase A inhibitors, wall teichoic acid inhibitors, and carbohydrate/protein-based agents.

Main Results:

  • Several classes of antivirulence compounds targeting Gram-positive adhesins have been identified.
  • These include inhibitors of sortase A, wall teichoic acid, and agents that bind bacterial proteins.
  • The review describes compounds influencing bacterial adhesion through various mechanisms.

Conclusions:

  • Antivirulence compounds targeting bacterial adhesion represent a promising avenue for novel antimicrobial development.
  • This strategy offers potential advantages in combating antibiotic-resistant pathogens.
  • Further research is needed to fully realize the therapeutic potential of these early-stage compounds.