[Serum hydrogen sulfide levels in children with benign infantile convulsions associated with mild gastroenteritis]

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Yuan-Da Zhang1, Fang Gu, Hui-Qing Xie

  • 1Baoding Children's Hospital, Baoding, Hebei 071000, China. ydzhang666@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 20, 2014
PubMed

Insights

Serum hydrogen sulfide (H2S) levels are significantly lower in children with benign infantile convulsions associated with mild gastroenteritis (BICE). Lower H2S levels correlate with increased seizure frequency and duration in these pediatric patients.

Area of Science:

  • Biochemistry
  • Pediatric Neurology

Context:

  • Benign infantile convulsions associated with mild gastroenteritis (BICE) are a common pediatric concern.
  • The role of endogenous gasotransmitters like hydrogen sulfide (H2S) in neurological conditions is an emerging area of research.

Purpose:

  • To investigate the serum levels of hydrogen sulfide (H2S) in children diagnosed with BICE.
  • To determine the correlation between serum H2S levels and the clinical characteristics of convulsions in BICE patients.

Summary:

  • Serum H2S levels were significantly lower in children with BICE compared to controls with acute gastroenteritis alone.
  • A negative correlation was observed between serum H2S levels and the number of convulsions.
  • Convulsion duration exceeding 5 minutes was also negatively correlated with serum H2S levels, suggesting a potential role in seizure severity.

Impact:

  • Findings suggest that reduced endogenous H2S may contribute to convulsions in BICE.
  • The degree of H2S reduction is linked to seizure frequency and duration.
  • Further research is warranted to elucidate the clinical implications of these biochemical alterations in pediatric epilepsy.
Abstract

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