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HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)
N Han1, S T Wright, C C O'Connor
1Beijing Ditan Hospital, Capital Medical University, Beijing, China.
HIV Medicine
|November 20, 2014
Summary
Older adults living with HIV/AIDS in the Asia Pacific face increased mortality risk. However, age did not significantly impact CD4 count changes or treatment modifications, suggesting similar outcomes across different healthcare settings.
Area of Science:
- Infectious Diseases
- Gerontology
- Public Health
Background:
- The proportion of individuals over 50 living with HIV/AIDS is rising globally.
- Understanding age-related treatment outcomes is crucial for this growing demographic.
Purpose of the Study:
- To investigate the association between older age and treatment outcomes in HIV-positive individuals in the Asia Pacific.
- To compare outcomes between resource-rich and resource-limited settings.
Main Methods:
- Analysis of data from the Australian HIV Observational Database (AHOD) and TREAT Asia HIV Observational Database (TAHOD).
- Utilized survival methods and regression analyses to assess mortality, CD4 count changes, viral load, and treatment modifications.
- Included 7142 patients, with 25% aged over 50.
Main Results:
- Individuals over 50 years old had at least double the risk of all-cause mortality compared to those aged 30-39.
- Older age was associated with a decreased odds of detectable viral load after combination antiretroviral therapy (cART).
- No significant differences in outcomes were observed between AHOD and TAHOD participants.
Conclusions:
- Age-related outcomes for HIV-positive patients in the Asia Pacific are consistent across different healthcare resource levels.
- Findings suggest that 'age effects' are comparable in both resource-rich and resource-limited settings.
- Future research on aging and HIV may be applicable across diverse settings.
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