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Updated: Apr 20, 2026

11:20
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
Published on: August 30, 2017
7.9K
Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles
Shuqing He1, Kristina Krippes, Sandra Ritz
1Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. wusi@mpip-mainz.mpg.de.
Abstract:
Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.

