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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
The role of human dendritic cells in HIV-1 infection
Zahra Ahmed1, Tatsuyoshi Kawamura2, Shinji Shimada2
1Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK.
Abstract:
Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
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