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Updated: Apr 20, 2026

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
A unified lead-oriented synthesis of over fifty molecular scaffolds
Richard G Doveston1, Paolo Tosatti, Mark Dow
1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. s.p.marsden@leeds.ac.uk a.s.nelson@leeds.ac.uk.
Abstract:
Controlling the properties of lead molecules is critical in drug discovery, but sourcing large numbers of lead-like compounds for screening collections is a major challenge. A unified synthetic approach is described that enabled the synthesis of 52 diverse lead-like molecular scaffolds from a minimal set of 13 precursors. The divergent approach exploited a suite of robust, functional group-tolerant transformations. Crucially, after derivatisation, these scaffolds would target significant lead-like chemical space, and complement commercially-available compounds.
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