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Updated: Apr 20, 2026

A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
Structure-odor relationships of semisynthetic β-santalol analogs
Céline Delasalle1, Claire A de March, Uwe J Meierhenrich
1Institute of Chemistry - Nice, University of Nice Sophia Antipolis, CNRS UMR 7272, Parc Valrose, FR-06108 Nice (phone: +33492076133; fax: +33492076125).
Abstract:
A series of eleven β-santalol analogs, including nine new derivatives, was prepared by semisynthesis from natural (-)-(Z)-β-santalol and studied by gas chromatography-olfactometry (GC-O) to characterize their olfactory properties and potencies. These compounds and 45 others selected in the literature were used to build three olfactophores by molecular modelling. Three models were obtained that gather structural and physicochemical constraints that will be useful for further design of new sandalwood odorants.
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