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Efficacy and tolerability of anticholinergics in Korean children with overactive bladder: a multicenter retrospective

Se Jin Park1, Ki Soo Pai1, Jun Mo Kim2

  • 1Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.

Journal of Korean Medical Science
|November 20, 2014
PubMed

Insights

Anticholinergic medications effectively improved overactive bladder (OAB) symptoms in Korean children, reducing incontinence and voiding frequency. Tolerability was good, with few discontinuing treatment due to side effects.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Non-neurogenic overactive bladder (OAB) is a common condition in children, impacting quality of life.
  • Anticholinergic medications are a cornerstone of OAB treatment, but their efficacy and tolerability in pediatric populations require further investigation.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of various anticholinergic treatments in Korean children diagnosed with non-neurogenic overactive bladder (OAB).

Main Methods:

  • Retrospective review of 326 Korean children (under 18 years) diagnosed with OAB between 2008 and 2011.
  • Analysis of symptom changes, voiding diaries, and uroflowmetry parameters before and after anticholinergic treatment.
  • Assessment of adverse effects and medication discontinuation rates.

Main Results:

  • Significant reductions in urgency urinary incontinence episodes (1.9 to 0.4/week) and daytime voiding frequency (9.2 to 6.3/day) were observed (P<0.001).
  • Bladder capacity increased significantly (maximum: 145.5 to 196.8 mL; average: 80.8 to 121.8 mL) (P<0.001).
  • Maximum flow rate on uroflowmetry improved (17.6 to 20.5 mL/sec) (P<0.001), with acceptable tolerability and low discontinuation rates (1.8%).

Conclusions:

  • Anticholinergic medications are effective in improving overactive bladder (OAB) symptoms in Korean children.
  • These treatments demonstrate good tolerability and are associated with minimal severe complications in this pediatric cohort.

Keywords:
AnticholinergicsEfficacyOveractive Urinary BladderTolerabilityUrinary Incontinence

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