Enzymatic aspects in ENT cancer-Matrix metalloproteinases
A A Zamfir Chiru1, C R Popescu2, D C Gheorghe3
1"Grigore Alexandrescu" Hospital, Bucharest, Romania.
Abstract:
The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a role in the clearance of cell surface receptors. They are expressed as zymogens (inactive forms). Proteolytic enzymes cleave zymogens generating active forms. They are involved in cell proliferation, adhesion, differentiation, migration, angiogenesis, apoptosis and host defense.
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