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Updated: Apr 20, 2026
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
Published on: January 18, 2020
Methylphenidate enhances neural stem cell differentiation
Jasmin Bartl1, Takatoshi Mori2, Peter Riederer3
1Hospital of Child and Adolescent Psychiatry, University of Zurich, Winterthurerstr. 180, Room L84/86, 8057 Zurich, Switzerland.
Background:
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).
Findings And Conclusion:
We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.
