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Post-stroke depression and the aging brain

Gabriel R Cojocaru1, Aurel Popa-Wagner2, Elena C Stanciulescu3

  • 1Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.

Journal of Molecular Psychiatry
|November 20, 2014
PubMed

Insights

Ageing impacts brain function and increases the risk of post-stroke depression (PSD). Understanding the genomic profile of the ageing brain and PSD mechanisms is crucial for elderly patient care.

Area of Science:

  • Neuroscience
  • Gerontology
  • Cardiovascular Medicine

Background:

  • Ageing alters organ system function, particularly the cardiovascular system, impacting brain health.
  • Cardiovascular changes contribute to neurological and cognitive impairments, increasing susceptibility to psychiatric disorders.
  • Post-stroke depression (PSD) is a common neuropsychiatric complication following cerebral ischemia.

Purpose of the Study:

  • To review animal models for studying PSD.
  • To summarize recent findings on the ageing brain's genomic profile related to age-associated disorders.
  • To explore the interplay between ageing, circadian rhythms, and PSD.

Main Methods:

  • Literature review of animal models for PSD research.
  • Synthesis of current research on the genomics of the ageing brain.
  • Discussion of the relationship between ageing, circadian rhythms, and PSD.

Main Results:

  • Animal models provide insights into PSD mechanisms.
  • Ageing brains exhibit specific genomic alterations linked to age-related disorders.
  • Circadian rhythm disruption is implicated in the development of PSD in the elderly.

Conclusions:

  • Deciphering basic mechanisms of PSD in ageing individuals offers significant clinical potential.
  • Targeting age-related genomic changes and circadian dysregulation may mitigate PSD.
  • Further research into the ageing brain and PSD is essential for improving elderly health outcomes.

Keywords:
AgingGene profilingPost stroke depressionStroke

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