Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.4K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.4K
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

6
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
6
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

7
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
7
Dementia l: Introduction01:22

Dementia l: Introduction

4
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
4
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.

Mechanisms of ageing and development·2026
Same author

Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions.

Ageing research reviews·2026
Same author

The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity.

Mechanisms of ageing and development·2026
Same author

A Pilot Study of a Cognitive-Behavioral and Meaning-Centered Intervention to Mitigate Doping-Related Distress.

Current health sciences journal·2026
Same author

Chronobiological disruption in ADHD: Developmental mechanisms linking sleep, behavior, and comorbid conditions.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Alginate gel embedding preserves antigenicity in free-floating brain sections.

Histology and histopathology·2026

Related Experiment Video

Updated: Apr 20, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

11.0K

Post-stroke depression and the aging brain.

Gabriel R Cojocaru1, Aurel Popa-Wagner2, Elena C Stanciulescu3

  • 1Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.

Journal of Molecular Psychiatry
|November 20, 2014
PubMed
Summary

Ageing impacts brain function and increases the risk of post-stroke depression (PSD). Understanding the genomic profile of the ageing brain and PSD mechanisms is crucial for elderly patient care.

Keywords:
AgingGene profilingPost stroke depressionStroke

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.6K

Related Experiment Videos

Last Updated: Apr 20, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

11.0K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.6K

Area of Science:

  • Neuroscience
  • Gerontology
  • Cardiovascular Medicine

Background:

  • Ageing alters organ system function, particularly the cardiovascular system, impacting brain health.
  • Cardiovascular changes contribute to neurological and cognitive impairments, increasing susceptibility to psychiatric disorders.
  • Post-stroke depression (PSD) is a common neuropsychiatric complication following cerebral ischemia.

Purpose of the Study:

  • To review animal models for studying PSD.
  • To summarize recent findings on the ageing brain's genomic profile related to age-associated disorders.
  • To explore the interplay between ageing, circadian rhythms, and PSD.

Main Methods:

  • Literature review of animal models for PSD research.
  • Synthesis of current research on the genomics of the ageing brain.
  • Discussion of the relationship between ageing, circadian rhythms, and PSD.

Main Results:

  • Animal models provide insights into PSD mechanisms.
  • Ageing brains exhibit specific genomic alterations linked to age-related disorders.
  • Circadian rhythm disruption is implicated in the development of PSD in the elderly.

Conclusions:

  • Deciphering basic mechanisms of PSD in ageing individuals offers significant clinical potential.
  • Targeting age-related genomic changes and circadian dysregulation may mitigate PSD.
  • Further research into the ageing brain and PSD is essential for improving elderly health outcomes.