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Related Experiment Video

Updated: Apr 20, 2026

Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization
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Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

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Photoacoustic lymphatic imaging with high spatial-temporal resolution.

Catherine Martel1, Junjie Yao2, Chih-Hsien Huang3

  • 1Washington University School of Medicine, Department of Pathology and Immunology, 425 S Euclid, St. Louis, Missouri 63110, United StatesbUniversité de Montréal, Faculty of Medicine; Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8.

Journal of Biomedical Optics
|November 20, 2014
PubMed
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Researchers developed a new photoacoustic microscopy system to visualize lymphatic vessels and flow dynamics. This advanced imaging tool aids in understanding lymphatic dysfunction in various diseases.

Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Lymphatic System Research

Background:

  • Lymphatic network dysfunction is understudied despite its role in immune cell trafficking and fluid balance.
  • Noninvasive imaging techniques are crucial for understanding lymphatic-related pathological disorders.

Purpose of the Study:

  • To develop and validate a novel noninvasive photoacoustic (PA) microscopy system.
  • To image lymphatic vasculature and flow dynamics with high resolution and sensitivity over a large field-of-view.

Main Methods:

  • Combined optical-resolution PA microscopy with a fast-scanning microelectromechanical system mirror.
  • Spectrally or temporally differentiated lymphatic vessels (LV) from blood vessels.
  • Performed validation experiments on phantoms and in vivo.

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Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
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Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
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Related Experiment Videos

Last Updated: Apr 20, 2026

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Published on: July 15, 2020

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Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
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Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

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Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
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Main Results:

  • Successfully imaged lymph dynamics over a large field-of-view with high spatial resolution and detection sensitivity.
  • Differentiated lymphatic vessels from blood vessels.
  • Visualized lymphatic flow dynamics in both nonpathological and pathological conditions.

Conclusions:

  • The newly developed PA microscopy system is a promising tool for lymphatic research.
  • This technology can advance the understanding of lymphatic-related biological processes and diseases.