Related Experiment Video
Updated: Apr 20, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
The safety of quinolones in pregnancy
Enav Yefet1, Raed Salim2, Bibiana Chazan3
1Department of Obstetrics & Gynecology, Emek Medical Center, Afula, Israel.
Abstract:
Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy. This review aimed to explore the mechanisms of action of the quinolones and fluoroquinolones, which set the stage for concerns regarding possible teratogenic and mutagenic effects; to clarify the clinical dilemmas that brought forth the necessity in reevaluating the use of those medications during pregnancy; and to review the accumulated data regarding their safety during pregnancy in animal models and humans.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Teratogenicity
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Radiological Investigation I: X-ray and CT
Drug Dosing: Infants and Children

