Related Experiment Video
Updated: Aug 13, 2026
14:55
Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors
Published on: December 3, 2013
Adenoviral fibrinous enteritis in calves
DTW. Deutsche Tierarztliche Wochenschrift
|April 1, 1989
Summary
Bovine adenovirus type 4 caused fibrinous enteritis and mucosal necrosis in two calves. Diagnosis involved identifying intranuclear inclusion bodies in intestinal and lymph cells, confirmed by electron microscopy and virus isolation.
Area of Science:
- Veterinary Pathology
- Virology
- Animal Health
Background:
- Fibrinous enteritis with mucosal necrosis is a significant gastrointestinal disease in calves.
- Intranuclear inclusion bodies are indicative of viral infections in animal tissues.
Purpose of the Study:
- To identify the causative agent of fibrinous enteritis in two affected calves.
- To characterize the pathological findings and confirm the viral etiology.
Main Methods:
- Post-mortem examination and histopathology of intestinal tissues.
- Ultrastructural analysis (electron microscopy) of inclusion bodies.
- Virus isolation and typing from affected tissues.
Main Results:
- Histopathology revealed fibrinous enteritis with mucosal necrosis, primarily in the ileocecal region.
- Amphophilic intranuclear inclusion bodies were observed in endothelial and lymphoid cells.
- Electron microscopy confirmed the presence of adenovirus particles within the inclusion bodies.
- Bovine adenovirus type 4 was successfully isolated and identified in one case.
Conclusions:
- Bovine adenovirus type 4 is identified as the causative agent of fibrinous enteritis and mucosal necrosis in these cases.
- The study highlights the diagnostic utility of histopathology and electron microscopy for identifying viral enteritis in calves.
Related Concept Videos
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...