Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

1.1K
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
1.1K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

2.0K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.4K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K
Chi-square Analysis02:46

Chi-square Analysis

45.1K
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
45.1K
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

238
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
238
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

958
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
958

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of musculoskeletal disorders among police officers from an organizational unit of a German federal state police force.

Journal of occupational medicine and toxicology (London, England)·2026
Same author

Socioeconomic determinants of COVID-19 incidence in a German rural area.

BMC public health·2026
Same author

Oral Hygiene Recommendations From Orthodontists to Orthodontic Patients.

International journal of dental hygiene·2026
Same author

Musculoskeletal complaints and psychosocial stress factors in emergency medical services: a differentiated gender comparison.

Journal of occupational medicine and toxicology (London, England)·2026
Same author

Ergonomic Risk Assessment of Professional Dance Using Motion Capture with Ergonomic Evaluation by the Rapid Entire Body Assessment (REBA).

Sensors (Basel, Switzerland)·2026
Same author

Influence of functional orthodontic therapy on body posture and postural control in children and adolescents with Class II malocclusion.

BMC oral health·2025

Related Experiment Video

Updated: Apr 20, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

34.6K

Curare--a curative poison: a scientometric analysis.

Jil Carl1, Mario Schwarzer1, Doris Klingelhoefer1

  • 1Institute for Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt, Germany.

Plos One
|November 20, 2014
PubMed
Summary
This summary is machine-generated.

This bibliometric analysis reveals that North America and Europe lead in curare research, with publication numbers peaking in the late 1990s. Research activity declined as interest in curare as a muscle relaxant waned.

More Related Videos

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

1.2K

Related Experiment Videos

Last Updated: Apr 20, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

34.6K
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

1.2K

Area of Science:

  • Pharmacology and Toxicology
  • Bibliometrics
  • History of Science

Background:

  • Curare, a well-studied neurotoxin, has historical use by Indigenous peoples.
  • A global scientometric analysis of curare research and its derivatives was previously unavailable.
  • This study forms part of the NewQis project, examining toxicological and historical aspects of curare research.

Purpose of the Study:

  • To conduct a bibliometric analysis of global curare research from 1900 to 2013.
  • To identify trends in publication output, geographic distribution, and research impact.
  • To correlate research activity with historical events and scientific developments.

Main Methods:

  • Searched the ISI Web of Science database for articles on curare published between 1900 and 2013.
  • Analyzed 3,867 articles for bibliometric indicators including citations and the Hirsch-Index (h-index).
  • Utilized density equalizing map projections (DEMP) and beam diagrams for data visualization.

Main Results:

  • The majority of publications originated from North America and Europe, with the USA leading in output and h-index.
  • Publication numbers increased until the late 1990s before declining.
  • Research surges correlated with historical events, such as the surgical use of curare as a muscle relaxant.

Conclusions:

  • The analysis highlights the scientific prominence of North America and Europe in curare research.
  • Decreased research activity reflects waning interest in curare as a muscle relaxant.
  • Scientometric methods effectively illuminate historical factors influencing scientific research.