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Related Experiment Video

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Multifunctional enveloped nanodevices (MENDs).

Yusuke Sato1, Takashi Nakamura1, Yuma Yamada1

  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo City, Hokkaido, Japan.

Advances in Genetics
|November 21, 2014
PubMed
Summary
This summary is machine-generated.

Nucleic acid medicines offer future cures by targeting gene expression. Multifunctional envelope-type nanodevices (MENDs) are crucial for delivering these therapies intracellularly, controlling biodistribution and trafficking.

Keywords:
A multifunctional envelope-type nanodevice (MEND)Intracellular traffickingKALAMITO-PoterMitochondrial targetingNuclear targetingOctaarginine (R8)Proton-activated lipid-like material (PALM)YSKpH-sensitive cationic lipid

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Area of Science:

  • Biotechnology and Nanomedicine
  • Gene Therapy and Drug Delivery

Background:

  • Nucleic acid medicines hold promise for treating diseases at the gene expression level.
  • Effective intracellular delivery is essential for nucleic acid therapies to function.

Purpose of the Study:

  • To review the development and evolution of multifunctional envelope-type nanodevices (MENDs).
  • To highlight MENDs' capability in controlling biodistribution and intracellular trafficking of nucleic acids.

Main Methods:

  • Development of MENDs, utilizing functional nucleic acids as a core with a lipid envelope.
  • Review of specific MEND examples: R8-MEND, KALA-MEND, MITO-Porter, YSK-MEND, and PALM.

Main Results:

  • MENDs demonstrate control over the biodistribution of nucleic acid medicines.
  • MENDs facilitate targeted intracellular trafficking, enhancing therapeutic efficacy.
  • Various MEND formulations have shown successful application in preclinical studies.

Conclusions:

  • Multifunctional envelope-type nanodevices are key to advancing nucleic acid therapy.
  • Continued development of MENDs is crucial for realizing the full potential of gene-based medicines.