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Bioelectronic light-gated transistors with biologically tunable performance.

Ramya H Tunuguntla1, Mangesh A Bangar, Kyunghoon Kim

  • 1Biology and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA; Materials Science and Chemical Engineering Department, University of California Davis, Davis, California, 95616, USA; The Molecular Foundry, Materials Sciences Division and.

Advanced Materials (Deerfield Beach, Fla.)
|November 21, 2014
PubMed
Summary

Bioelectronic devices utilize light-activated bacteriorhodopsin proton pumps on silicon nanowires. This light-induced pH change modulates transistor output, enabling tunable bioelectronic sensing applications.

Keywords:
bacteriorhodopsinbioelectronicsbiological regulationionophoressilicon nanowire field-effect transistors (FETs)

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Area of Science:

  • Bioelectronics
  • Nanotechnology
  • Biophysics

Background:

  • Bacteriorhodopsin (bR) is a light-activated proton pump.
  • Silicon nanowires are versatile semiconductor materials for electronic devices.
  • Bioelectronic interfaces merge biological components with electronic systems.

Purpose of the Study:

  • To develop light-activated bioelectronic silicon nanowire transistor devices.
  • To investigate the mechanism of light-induced proton pumping by bR on nanowires.
  • To explore methods for modulating the device response using biomolecular co-assembly.

Main Methods:

  • Fusing proteoliposomes containing bacteriorhodopsin (bR) onto silicon nanowire surfaces.
  • Utilizing green-light illumination to activate the bR proton pump.
  • Measuring changes in transistor output due to pH gradients.
  • Co-assembling biomolecules to alter membrane permeability.

Main Results:

  • Light-activated bR pumps protons toward the nanowire, creating a pH gradient.
  • The developed pH gradient alters the transistor output.
  • Co-assembly of biomolecules can upregulate and downregulate the field-effect transistor response.

Conclusions:

  • Light-activated bacteriorhodopsin on silicon nanowires creates functional bioelectronic devices.
  • The device response can be tuned by controlling ion permeability through biomolecular co-assembly.
  • These findings offer a pathway for developing novel light-gated bioelectronic sensors.