Relationship between urodynamic findings and sexual function in multiple sclerosis patients with lower urinary tract...

Area of Science:

• Urology
• Neurology
• Sexual Medicine

Background:

• Sexual dysfunction (SD) and lower urinary tract dysfunction (LUTD) are prevalent in multiple sclerosis (MS) patients, impacting quality of life.
• Understanding the link between urinary function and SD is crucial for comprehensive MS patient care.

Purpose of the Study:

• To investigate the relationship between urodynamic findings and sexual dysfunction in a cohort of MS patients experiencing LUTD.
• To identify specific urodynamic parameters that predict sexual dysfunction in this population.

Main Methods:

• 135 MS patients with LUTD underwent urodynamic examination, Expanded Disability Status Scale assessment, and SD evaluation using FSFI or IIEF-15.
• Multivariate logistic regression analyzed predictors of female SD (FSFI < 26.55) or moderate-severe erectile dysfunction (ED) (IIEF-EF ≤ 16).

Main Results:

• Higher maximum detrusor pressure during involuntary detrusor contraction (PdetmaxIDC ≥20.0 cmH2 O) was associated with lower erectile function and satisfaction scores.
• Lower maximum cystometric capacity (MCC <135 ml) and reduced compliance (≤3 ml/cmH2 O) were significant predictors of moderate-severe ED.
• No significant relationship was found between these urodynamic parameters and female SD (FSFI < 26.55).

Conclusions:

• Neurogenic bladder, characterized by specific urodynamic findings, is associated with sexual dysfunction in MS patients.
• PdetmaxIDC ≥20 cmH2 O, MCC <135 ml, and compliance ≤3 ml/cmH2 O are significant predictors of moderate-to-severe erectile dysfunction in MS patients.