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Is there still hope for single therapies: how do we set up experimental systems to efficiently test combination

Guy F Joos1, Esteban C Gabazza

  • 1Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

Respirology (Carlton, Vic.)
|November 21, 2014
PubMed

Insights

Developing new therapies for severe asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) requires improved preclinical models. Transgenic mice overexpressing disease genes can reveal new pathways and aid targeted therapy development for chronic lung diseases.

Area of Science:

  • Pulmonary Medicine
  • Translational Research
  • Genetics

Background:

  • Severe asthma, COPD, and IPF are chronic lung diseases lacking sufficient therapeutic options.
  • Current preclinical mouse models present challenges in translating research to clinical practice.
  • Disease heterogeneity complicates treatment efficacy and clinical outcomes.

Purpose of the Study:

  • To highlight the need for enhanced experimental models in chronic lung diseases.
  • To explore the potential of transgenic mouse models for discovering novel therapeutic targets.
  • To discuss the role of personalized medicine in addressing disease heterogeneity.

Main Methods:

  • Review of existing preclinical research methodologies for chronic lung diseases.
  • Conceptualization of transgenic mouse models overexpressing disease-related genes.
  • Discussion of challenges in translational research from basic science to clinical application.

Main Results:

  • Mouse models are crucial but require improvement for better clinical translation.
  • Transgenic mice offer a promising avenue for identifying new pathological pathways.
  • Molecular targeted therapy and personalized medicine are key future directions.

Conclusions:

  • Upgrading experimental disease models is essential for advancing chronic lung disease treatment.
  • Transgenic mouse models can accelerate the discovery of targeted therapies.
  • Personalized medicine holds potential for improving patient outcomes in heterogeneous lung diseases.
Keywords:
asthmachronic obstructive pulmonary diseaseinhalation therapyinterstitial pulmonary disease

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