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Global displacement of canine parvovirus by a host-adapted variant: structural comparison between pandemic viruses
Lindsey J Organtini1, Andrew B Allison2, Tiit Lukk3
1Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Abstract:
Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
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