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Related Experiment Video

Updated: Apr 20, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Electrical carotid baroreceptor stimulation.

Jürg Schmidli¹, Regula S von Allmen, Markus G Mohaupt

¹Dept of Cardiovascular Surgery, Bern University Hospital, 3010, Bern, Switzerland, juerg.schmidli@insel.ch.

Wiener Medizinische Wochenschrift (1946)

|November 21, 2014

Summary

The Barostim neo system activates the carotid baroreflex, lowering blood pressure and heart rate in resistant hypertension patients. This novel device also shows promise in improving heart failure symptoms and cardiac remodeling.

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Area of Science:

Cardiovascular Medicine
Biomedical Engineering

Background:

Resistant hypertension poses a significant clinical challenge.
Cardiac remodeling and heart failure are associated with high morbidity and mortality.

Purpose of the Study:

To evaluate the efficacy and safety of the Barostim neo system for treating resistant hypertension.
To assess the impact of baroreflex activation therapy on cardiac remodeling and heart failure parameters.

Main Methods:

The Barostim neo system, an implantable device, electrically activates the carotid baroreflex.
Long-term studies tracked blood pressure, heart rate, cardiac remodeling markers, and quality of life in patients.

Main Results:

Consistent reduction in systolic blood pressure (up to 53 mmHg) observed over 4 years in resistant hypertension patients.
Demonstrated reduction in left ventricular mass and posterior wall thickness.
Improved quality of life and functional capacity in heart failure patients with decreased sympathetic nerve activity.

Conclusions:

Baroreflex activation therapy using the Barostim neo system is a safe and effective treatment for resistant hypertension.
The therapy offers potential benefits for cardiac remodeling and heart failure management.