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Updated: Apr 20, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Anti-TNF therapy: past, present and future.
Claudia Monaco1, Jagdeep Nanchahal1, Peter Taylor1
1Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK.
Biologic therapies, including monoclonal antibodies, are revolutionizing medicine beyond traditional small molecules. These protein-based drugs effectively treat inflammatory diseases and cancer, marking a significant shift in therapeutic approaches.
Area of Science:
- Biotechnology
- Immunology
- Pharmacology
Background:
- Therapeutics historically relied on small molecule drugs.
- Protein-based biologic therapies have emerged as crucial treatments.
- Biologics offer improved efficacy for inflammatory diseases and cancer.
Purpose of the Study:
- To review the development and impact of biologic therapies.
- To highlight the role of monoclonal antibodies in modern medicine.
- To discuss future applications of anti-tumour necrosis factor (TNF) agents.
Main Methods:
- Review of scientific literature on biologic drug development.
- Case study of infliximab for rheumatoid arthritis (RA).
- Analysis of TNF as a therapeutic target.
Main Results:
- Biologics, particularly monoclonal antibodies, have transformed treatment landscapes.
- Infliximab, an anti-TNF biologic, demonstrated significant success in RA.
- Biologics represent the fastest-growing sector in therapeutics.
Conclusions:
- Biologic therapies have expanded treatment options and improved patient outcomes.
- Targeting specific molecules like TNF has proven highly effective.
- Continued research promises further advancements in biologic therapeutics.
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