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Whole-body and hepatic insulin resistance in obese children

Lorena del Rocío Ibarra-Reynoso1, Liudmila Pisarchyk1, Elva Leticia Pérez-Luque1

  • 1Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.

Plos One
|November 21, 2014
PubMed

Insights

In obese children, BMI best predicts whole-body insulin resistance, while waist-to-height ratio predicts hepatic insulin resistance. These findings highlight central obesity

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome Research
  • Obesity Studies

Background:

  • Insulin resistance can manifest as whole-body or hepatic.
  • Understanding factors contributing to both is crucial for pediatric metabolic health.

Purpose of the Study:

  • To investigate factors associated with whole-body and hepatic insulin resistance in obese children.
  • To identify key anthropometric and metabolic predictors.

Main Methods:

  • Cross-sectional study of 182 obese children.
  • Assessed insulin resistance using HOMA-IR (whole-body) and IGFBP-1 levels (hepatic).
  • Compared BMI, waist-to-height ratio, visceral adiposity, and measured hormone and metabolite levels.

Main Results:

  • 73.1% of obese children exhibited both whole-body and hepatic insulin resistance.
  • HOMA-IR correlated positively with BMI, triglycerides, and leptin; IGFBP-1 correlated negatively with waist-to-height ratio and HOMA-IR.
  • No association found between HOMA-IR/IGFBP-1 and fatty liver.

Conclusions:

  • BMI is the optimal predictor for whole-body insulin resistance in children.
  • Waist-to-height ratio is the best predictor for hepatic insulin resistance, underscoring central obesity's role.
  • The inverse relationship between IGFBP-1 and HOMA-IR suggests interconnected physiological pathways.
Abstract

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