Jiangrines A-F and jiangolide from an actinobacterium, Jiangella gansuensis

Seven new compounds, including five pyrrol-2-aldehyde derivatives, jiangrines A-E (1-5), one indolizine derivative, jiangrine F (7), and one glycolipid, jiangolide (8), along with a known compound, pyrrolezanthine (6), were isolated from the fermentation broth of Jiangella gansuensis, an actinobacterium assigned to a novel family, Jiangellaceae, and a novel order, Jiangellales. The structures were elucidated by detailed spectroscopic analysis and through chemical methods. Compounds 1, 2, 3/4, 5, 6, and 8 demonstrated inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells, with IC50 values of 97.8, 60.7, 30.1, 54.9, 58.8, and 61.4 μM, respectively.