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Published on: January 7, 2022
β-Carboline alkaloids from Galianthe ramosa inhibit malate synthase from Paracoccidioides spp
Carla S de Freitas1, Lucilia Kato1, Cecília M A de Oliveira1
1Instituto de Química - Universidade Federal de Goiás, Goiânia, GO, Brazil.
Abstract:
As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.
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