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Avidity of antiphospholipid antibodies - our current knowledge
Summary
High avidity antiphospholipid antibodies (APL) are linked to thrombosis and antiphospholipid syndrome (APS). Determining APL avidity may aid in APS classification.
Area of Science:
- Immunology
- Clinical Chemistry
Background:
- Antiphospholipid antibodies (APL) are heterogeneous autoantibodies.
- APL are serum markers for antiphospholipid syndrome (APS).
- APL heterogeneity includes antigen-binding specificity and avidity.
Purpose of the Study:
- To review methods for determining APL avidity.
- To evaluate the clinical significance of APL avidity.
Main Methods:
- Review of commonly used avidity determination procedures.
- Focus on Enzyme-Linked Immunosorbent Assays (ELISAs) with chaotropic agents.
Main Results:
- High avidity APL correlate with thrombosis.
- High avidity APL are associated with APS.
- APL avidity determination may classify APS.
Conclusions:
- APL avidity is a crucial characteristic.
- Avidity assays offer insights into APS pathogenesis.
- APL avidity determination can be a complementary diagnostic marker for APS.
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