Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.3K
T Cell Types and Functions01:24

T Cell Types and Functions

3.6K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.6K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.9K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.5K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved Systemic Immunochemotherapy Employing an Oxaliplatin-TLR7/8 Agonist Prodrug Strategy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Transpresentation of interleukin 15 by stromal cell subsets regulates immune cell homeostasis.

Frontiers in immunology·2026
Same author

Spatial organization of stromal subtypes stratifies colorectal cancer patients and predicts clinical outcomes.

Cancer letters·2025
Same author

<i>Rroid2</i> regulates effector-to-memory CD8<sup>+</sup> T cell differentiation during infection in vivo.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis.

Cancer research·2025
Same author

Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis.

Nature communications·2025

Related Experiment Video

Updated: Apr 20, 2026

In Vitro Differentiation of Mouse Granulocyte-macrophage-colony-stimulating Factor GM-CSF-producing T Helper THGM Cells
10:27

In Vitro Differentiation of Mouse Granulocyte-macrophage-colony-stimulating Factor GM-CSF-producing T Helper THGM Cells

Published on: September 10, 2018

7.7K

Producing GM-CSF: a unique T helper subset?

Dietmar Herndler-Brandstetter1, Richard A Flavell2

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell Research
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing T cells are crucial for autoimmune inflammation. Their differentiation from naive CD4 T cells is distinct from Th1/Th17 cells and regulated by the IL-7-STAT5 pathway.

More Related Videos

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

6.0K
Generation of Large Numbers of Myeloid Progenitors and Dendritic Cell Precursors from Murine Bone Marrow Using a Novel Cell Sorting Strategy
09:05

Generation of Large Numbers of Myeloid Progenitors and Dendritic Cell Precursors from Murine Bone Marrow Using a Novel Cell Sorting Strategy

Published on: August 10, 2018

9.8K

Related Experiment Videos

Last Updated: Apr 20, 2026

In Vitro Differentiation of Mouse Granulocyte-macrophage-colony-stimulating Factor GM-CSF-producing T Helper THGM Cells
10:27

In Vitro Differentiation of Mouse Granulocyte-macrophage-colony-stimulating Factor GM-CSF-producing T Helper THGM Cells

Published on: September 10, 2018

7.7K
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

6.0K
Generation of Large Numbers of Myeloid Progenitors and Dendritic Cell Precursors from Murine Bone Marrow Using a Novel Cell Sorting Strategy
09:05

Generation of Large Numbers of Myeloid Progenitors and Dendritic Cell Precursors from Murine Bone Marrow Using a Novel Cell Sorting Strategy

Published on: August 10, 2018

9.8K

Area of Science:

  • Immunology
  • Cell Biology
  • Autoimmunity

Background:

  • GM-CSF-producing T cells play a key role in initiating autoimmune inflammation.
  • Understanding the differentiation pathways of these cells is critical for developing targeted therapies.

Purpose of the Study:

  • To investigate the distinct differentiation program of GM-CSF-producing T cells.
  • To identify the regulatory mechanisms governing this differentiation process.

Main Methods:

  • Analysis of T cell differentiation from naive CD4 T cells.
  • Investigation of the role of the IL-7-STAT5 signaling axis.

Main Results:

  • The differentiation program for GM-CSF-producing T cells is distinct from Th1 and Th17 cells.
  • The IL-7-STAT5 axis regulates the differentiation of GM-CSF-producing T cells.

Conclusions:

  • GM-CSF-producing T cells represent a unique T cell subset with a distinct differentiation pathway.
  • Targeting the IL-7-STAT5 axis could offer novel therapeutic strategies for autoimmune diseases.