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Updated: Apr 20, 2026

In Vitro Differentiation of Mouse Granulocyte-macrophage-colony-stimulating Factor GM-CSF-producing T Helper THGM Cells
Published on: September 10, 2018
Producing GM-CSF: a unique T helper subset?
Dietmar Herndler-Brandstetter1, Richard A Flavell2
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Abstract:
GM-CSF-producing helper T cells have previously been identified to serve a nonredundant function in the initiation of autoimmune inflammation. An article by Sheng et al. recently published by Cell Research now suggests that the differentiation program of GM-CSF-producing cells from naïve CD4 T cells is distinct from that of Th1 and Th17 cells, and is regulated by the IL-7-STAT5 axis.
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