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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Pleiotropy01:33

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Overview
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Genetics of psoriasis.

Satveer K Mahil1, Francesca Capon2, Jonathan N Barker1

  • 1Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, King's College London, 9th Floor, Tower Wing, London SE1 9RT, UK.

Dermatologic Clinics
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PubMed
Summary
This summary is machine-generated.

Genetic studies reveal psoriasis susceptibility genes linked to immune responses and skin barrier function. This knowledge may enable personalized treatments with fewer adverse effects for this common skin disease.

Keywords:
GeneticsGenome-wide association studiesPsoriasisStratification

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Area of Science:

  • Immunodermatology
  • Genetics of skin diseases
  • Immune-mediated disorders

Background:

  • Psoriasis is a prevalent, chronic immune-mediated skin condition.
  • Its pathogenesis is complex and influenced by genetic factors.
  • Understanding genetic underpinnings is crucial for effective management.

Purpose of the Study:

  • To review genetic association studies in psoriasis.
  • To identify genes associated with psoriasis susceptibility.
  • To explore the role of these genes in immune function and skin barrier.

Main Methods:

  • Focus on results from genetic association studies.
  • Analysis of evidence linking specific genes to psoriasis.
  • Review of literature on immune and skin barrier pathways.

Main Results:

  • Psoriasis susceptibility genes are implicated in both innate and adaptive immunity.
  • Genetic factors also play a role in maintaining skin barrier integrity.
  • Evidence suggests a polygenic basis for the disease.

Conclusions:

  • Genetic data offers potential for stratifying psoriasis patients.
  • This stratification can guide the development of targeted therapies.
  • Future treatments may offer improved efficacy and reduced side effects.