Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

9.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.8K
Complement System01:27

Complement System

13.2K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
13.2K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.1K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.1K
Nephrons01:10

Nephrons

10.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
10.0K
Glomerular Filtration01:15

Glomerular Filtration

7.9K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
7.9K
Humoral Immune Responses01:36

Humoral Immune Responses

88.3K
Overview
88.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paclitaxel- or sirolimus-coated balloons used for ArterioVEnous fistulas-2 (PAVE-2): study protocol for a randomised controlled trial to determine the efficacy of paclitaxel- or sirolimus-coated balloons in arteriovenous fistulas used for haemodialysis.

Trials·2024
Same author

Author Correction: Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula.

Scientific reports·2023
Same author

The authors reply.

Kidney international·2023
Same author

Antimyeloperoxidase antibodies modulate inflammatory responses and activate profibrotic pathways in human monocytes.

Journal of autoimmunity·2023
Same author

Experimentally Induced Anti-Myeloperoxidase Vasculitis Is Not Attenuated in Factor B or VISTA Deficient Mice.

Glomerular diseases·2023
Same author

Corrigendum to "Humanised mice have functional human neutrophils" [Journal of Immunological Methods, Volume 385, Issues 1-2, 30 November 2012, Pages 96-104].

Journal of immunological methods·2023
Same journal

Proceedings of the 5th Annual UAB-UCSD O'Brien Center Symposium, March 4, San Diego, California.

Nephron. Clinical practice·2015
Same journal

Proceedings of the 19th International Conference on Continuous Renal Replacement Therapies, March 2-3, 2014, San Diego, California, USA.

Nephron. Clinical practice·2015
Same journal

Chronic kidney disease in disadvantaged populations.

Nephron. Clinical practice·2015
Same journal

Differential membrane expression of Toll-like receptors and intracellular cytokine induction in peripheral blood monocytes of patients with chronic kidney disease and diabetic nephropathy.

Nephron. Clinical practice·2015
Same journal

Correction of hyper- and hyponatraemia during continuous renal replacement therapy.

Nephron. Clinical practice·2015
Same journal

Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.

Nephron. Clinical practice·2015
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.7K

Complement and glomerular diseases.

Reena J Popat1, Michael G Robson

  • 1King's College London, London, UK.

Nephron. Clinical Practice
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

The complement pathway is crucial in kidney diseases, impacting both innate and adaptive immunity. Understanding its role in glomerular diseases offers new therapeutic targets.

More Related Videos

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.2K

Related Experiment Videos

Last Updated: Apr 20, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.7K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.2K

Area of Science:

  • Immunology
  • Nephrology
  • Pathogenesis of Glomerular Diseases

Background:

  • The complement pathway is integral to the immune system, influencing innate and adaptive responses.
  • Clinical evidence, including biopsy findings and genetic data, links complement to glomerular disease pathogenesis.
  • Animal models provide mechanistic insights into complement's role in kidney pathology.

Purpose of the Study:

  • To review the role of the complement system in the pathogenesis of glomerular diseases.
  • To discuss evidence from human patients and animal models for specific glomerular diseases.
  • To explore potential therapeutic implications targeting the complement pathway.

Main Methods:

  • Review of clinical findings in patients with glomerular diseases.
  • Analysis of data from animal models of glomerular diseases.
  • Synthesis of information on complement components, autoantibodies, and genetic mutations.

Main Results:

  • Complement activation is implicated in atypical hemolytic uremic syndrome, C3 glomerulopathy, ANCA vasculitis, lupus nephritis, and membranous nephropathy.
  • Presence of complement in biopsies and genetic factors correlate with disease development.
  • Consumption of complement factors in circulation indicates active disease.

Conclusions:

  • The complement pathway plays a significant role in the development and progression of various glomerular diseases.
  • Targeting the complement system presents a promising therapeutic strategy for managing these kidney conditions.
  • Further research into complement-mediated mechanisms can refine treatment approaches for glomerular pathologies.