Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Paramyxovirus SV5 and multiple sclerosis.

B Vandvik¹, E Norrby

¹Institute of Immunology and Rheumatology, Rikshospitalet National Hospital, University of Oslo School of Medicine, Norway.

|April 27, 1989

Summary

This study investigated the link between Simian Virus 5 (SV5) and multiple sclerosis (MS). Researchers found no strong evidence that SV5 antibodies are a major cause of the intrathecal immune response observed in MS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monoclonal antibodies against morbilliviruses.

Revue scientifique et technique (International Office of Epizootics)·2020

Same author

Prions and protein-folding diseases.

Journal of internal medicine·2011

Same author

MS and clinically isolated syndromes: shared specificity but diverging clonal patterns of virus-specific IgG antibodies produced in vivo and by CSF B cells in vitro.

European journal of neurology·2009

Same author

GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistence.

European journal of neurology·2008

Same author

T cells from multiple sclerosis patients recognize immunoglobulin G from cerebrospinal fluid.

Multiple sclerosis (Houndmills, Basingstoke, England)·2003

Same author

Diagnostic validity of somatosensory evoked potentials in subgroups of patients with sciatica.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2002

Area of Science:

Neuroimmunology
Virology
Central Nervous System Disorders

Background:

Multiple sclerosis (MS) is characterized by an immune response within the central nervous system (CNS).
Oligoclonal IgG bands in cerebrospinal fluid (CSF) are a hallmark of this intrathecal immune response in MS patients.
Previous research suggested Simian Virus 5 (SV5) might be involved in MS pathogenesis.

Purpose of the Study:

To investigate the potential role of SV5 as a major intrathecal immunogen in multiple sclerosis.
To determine if antibodies reacting with SV5 are associated with oligoclonal IgG bands in MS patients' CSF.

Main Methods:

Studied thirty patients diagnosed with multiple sclerosis.
Analyzed cerebrospinal fluid (CSF) for intrathecal synthesis of IgG antibodies.
Tested for antibodies reacting with SV5 and other paramyxoviruses.
Assessed the association of identified antibodies with oligoclonal IgG bands in CSF.

Main Results:

Intrathecal synthesis of IgG antibodies reacting with SV5 was found in seven out of thirty MS patients.
These SV5-reactive antibodies were not associated with the presence of oligoclonal IgG bands in CSF.
The identified antibodies could be explained as cross-reacting with other known human paramyxoviruses.

Conclusions:

The study could not confirm SV5 as a major intrathecal immunogen in multiple sclerosis.
The findings suggest that observed SV5-reactive antibodies in MS patients may be due to cross-reactivity with other viruses.
The link between SV5 and the characteristic intrathecal immune response in MS remains unproven by this study.

Related Experiment Videos