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Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles
Alessandro Poma1, Heli Brahmbhatt, Hannah M Pendergraff
1Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK.
Advanced Materials (Deerfield Beach, Fla.)
|November 22, 2014
Abstract:
A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified "aptamer monomer" results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.
