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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Bed rest does not induce hypercoagulability.

Gerhard Cvirn1, James Elvis Waha, Gerhard Ledinski

  • 1Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria.

European Journal of Clinical Investigation
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

Long-term bed rest does not increase hypercoagulability in healthy individuals. Instead, it may lead to a hypocoagulable state, with a shift towards hypercoagulability upon re-ambulation.

Keywords:
Anticoagulantsblood coagulationimmobilizationthrombelastographythrombin

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Area of Science:

  • Hematology
  • Physiology

Background:

  • Immobilization and bed rest are commonly believed to induce hypercoagulability.
  • Anticoagulants are often administered to immobilized patients due to this belief.
  • Direct evidence linking bed rest to increased thromboembolic risk is lacking.

Purpose of the Study:

  • To investigate the effect of long-term bed rest on the hemostatic system.
  • To determine if bed rest increases the risk of thromboembolic events.

Main Methods:

  • Eleven healthy male subjects underwent a bed rest campaign.
  • Calibrated automated thrombography (CAT) and thrombelastometry (TEM) were employed.
  • Sensitive detection of hyper- or hypocoagulable states was achieved using activated tissue factor.

Main Results:

  • Bed rest did not induce hypercoagulability; instead, a hypocoagulable state was observed.
  • Peak thrombin and velocity index (VELINDEX) significantly decreased during bed rest.
  • Coagulation times increased, and alpha angles decreased, indicating reduced clot formation.

Conclusions:

  • Bed rest itself does not appear to cause hypercoagulable states in healthy subjects.
  • A tendency towards hypercoagulability was observed during the re-ambulation period following bed rest.
  • Re-ambulation was associated with shorter ttPeak and StartTail, and higher Peak and VELINDEX.