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Integrated Testing Strategies (ITS) for safety assessment.

Costanza Rovida1, Nathalie Alépée, Anne M Api

  • 1CAAT Europe, University of Konstanz, Germany.

ALTEX
|November 22, 2014
PubMed
Summary

Integrated testing strategies (ITS) efficiently combine data for regulatory safety assessments. This approach, exemplified by skin sensitization testing, requires new concepts like adverse outcome pathways and machine learning.

Area of Science:

  • Toxicology and regulatory science
  • In vitro and in silico testing methodologies

Background:

  • Increasing limitations of individual toxicological tests necessitate integrated approaches.

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  • The development of targeted assays and predictive models heightens the need for evidence integration.
  • Regulatory safety assessments require robust methods for combining diverse data sources.