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The IPD and IMGT/HLA database: allele variant databases.

James Robinson¹, Jason A Halliwell², James D Hayhurst²

¹Anthony Nolan Research Institute, Hampstead, London, NW3 2QG, UK UCL Cancer Institute, University College London, Hampstead, London, NW3 2QG, UK.

Nucleic Acids Research

|November 22, 2014

Summary

This summary is machine-generated.

The Immuno Polymorphism Database (IPD) centralizes genetic polymorphism data for the immune system, particularly the Major Histocompatibility Complex (MHC). It provides curated, publicly accessible data for researchers and clinicians.

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Area of Science:

Immunogenetics
Bioinformatics
Genomics

Background:

Polymorphism in immune system genes, especially the Major Histocompatibility Complex (MHC), is crucial for immune function and disease susceptibility.
A centralized, curated resource for this complex genetic data was lacking, hindering research and clinical applications.

Purpose of the Study:

To establish and maintain the Immuno Polymorphism Database (IPD) as a central platform for immune gene polymorphism data.
To facilitate the curation, publication, and public access of locus-specific databases, including the IMGT/HLA Database.

Main Methods:

Collaboration with specialist groups and nomenclature committees for data curation.
Online publication of curated data through the IPD website, hosted at the European Bioinformatics Institute.
Integration of new tools to support advancements like Next Generation Sequencing.

Main Results:

Established IPD as a central hub for five core databases, with IMGT/HLA as the primary resource.
Provided public access to extensive immunogenetic data via http://www.ebi.ac.uk/ipd/.
Regular updates ensure the dissemination of new and confirmatory sequence data.

Conclusions:

The IPD project successfully created a vital resource for the immunogenetics community.
Ongoing development and updates ensure the IPD remains relevant for current and future research in immunogenetics and related fields.