Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.2K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.2K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

1.1K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
1.1K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

7.1K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
7.1K
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

1.5K
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
1.5K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

17.3K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
17.3K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.4K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UCI Sports Nutrition Project: Race Nutrition for Road Cycling.

International journal of sport nutrition and exercise metabolism·2026
Same author

Remodeling of the Mouse Liver and Skeletal Muscle Metabolome in Response to Continuous Acute Exercise and Disruption of AMPK-Glycogen Interactions.

Metabolites·2026
Same author

Carbohydrate restriction drives greater perturbations in circulating metabolites than low energy availability in elite male athletes.

Physiological reports·2026
Same author

UCI Sports Nutrition Project: Nutrition for the Emerging Cycling Disciplines of Esports and Gravel.

International journal of sport nutrition and exercise metabolism·2026
Same author

UCI Sports Nutrition Project: Considerations and Applications for the Use of Sports Foods and Supplements to Improve Performance in Cycling.

International journal of sport nutrition and exercise metabolism·2026
Same author

Rehydration After Exercise-Induced Fluid Losses: Comparing Flavored Water, Coconut Water, and Carbohydrate-Electrolyte Sports Beverage.

Journal of strength and conditioning research·2025

Related Experiment Video

Updated: Apr 20, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

27.8K

Taurine and skeletal muscle function.

Lawrence L Spriet1, Jamie Whitfield

  • 1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

Current Opinion in Clinical Nutrition and Metabolic Care
|November 22, 2014
PubMed
Summary

Taurine is vital for skeletal muscle function, aiding contraction and antioxidant defense. However, oral taurine supplementation effectively increases muscle taurine in rodents but not humans due to transport resistance.

More Related Videos

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
05:50

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

Published on: June 13, 2017

9.0K
Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle
10:53

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle

Published on: December 1, 2023

4.6K

Related Experiment Videos

Last Updated: Apr 20, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

27.8K
Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
05:50

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

Published on: June 13, 2017

9.0K
Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle
10:53

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle

Published on: December 1, 2023

4.6K

Area of Science:

  • Muscle Physiology
  • Nutritional Biochemistry
  • Cellular Biology

Background:

  • Taurine is an amino acid crucial for skeletal muscle function.
  • Key roles include facilitating excitation-contraction coupling, regulating cell volume, and providing antioxidant defense.
  • Research has primarily focused on rodent models to understand taurine's effects.

Purpose of the Study:

  • To review the significance of taurine in skeletal muscle.
  • To highlight the differences in taurine research findings between rodent and human skeletal muscle.
  • To identify future research directions for taurine supplementation in humans.

Main Methods:

  • Review of existing scientific literature on taurine in skeletal muscle.
  • Comparison of experimental results from rodent and human studies.
  • Analysis of taurine transport mechanisms and cellular responses.

Main Results:

  • Normal taurine levels are essential for skeletal muscle function.
  • Rodent studies show increased muscle taurine and function with dietary supplementation.
  • Human skeletal muscle resists increased taurine uptake from oral supplementation due to transport mechanisms.
  • Current methods to enhance human muscle function with taurine involve extra-cellular interactions.

Conclusions:

  • Future research must investigate taurine transport mechanisms into human skeletal muscle.
  • Understanding why human muscle defends its taurine content is critical.
  • This knowledge may enable effective taurine supplementation for athletic and clinical benefits.