Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

518
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
518
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

891
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
891
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

666
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
666
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

373
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
373
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

944
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
944

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Value-Based Healthcare analysis of antibiotic administration in non-hospital settings: assessment of patient benefits and economic sustainability of the system.]

Recenti progressi in medicina·2026
Same author

Pancreatic Cystic Lesions and Endoscopic Ultrasound Diagnostic Equipment: A Literature Review.

Journal of clinical medicine·2026
Same author

Dupilumab in Severe Asthma-COPD Overlap: Real-Life Experience on a Case Series.

Journal of personalized medicine·2026
Same author

Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study.

Thoracic research and practice·2026
Same author

Real-Life Efficacy of Single-Inhaler Triple Therapy with Budesonide/Glycopyrronium/Formoterol Fumarate in Persistent COPD Users: A Retrospective Database Study.

Biomedicines·2025
Same author

Infantile Colic: When to Suspect Cow's Milk Allergy.

Nutrients·2025

Related Experiment Video

Updated: Apr 20, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.5K

Serum reference values for leptin in healthy infants.

Francesco Savino1, Lorenza Rossi1, Stefania Benetti1

  • 1Department of Paediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.

Plos One
|November 22, 2014
PubMed
Summary

This study establishes crucial serum leptin reference values for infants under 18 months, finding higher levels in breast-fed babies during the first six months. These findings provide essential data for pediatric health assessments.

More Related Videos

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.3K
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.6K

Related Experiment Videos

Last Updated: Apr 20, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.5K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.3K
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.6K

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Metabolism
  • Growth and Development

Background:

  • Leptin reference values are lacking for infants in early life.
  • Establishing these values is critical for pediatric health monitoring.

Purpose of the Study:

  • Determine serum leptin reference values for healthy infants up to 18 months.
  • Provide age- and feeding-based reference ranges for leptin concentrations.

Main Methods:

  • Radioimmunoassay was used to measure serum leptin in 317 healthy infants (2002-2012).
  • Quantile regression calculated median and 10th-90th percentiles for reference values.
  • Results were compared with an independent cohort of 110 infants.

Main Results:

  • Median serum leptin was 2.37 ng/ml overall; higher in infants <6 months (2.81 ng/ml) than older infants.
  • Breast-fed infants had significantly higher leptin levels than formula-fed infants in the first 6 months (2.63 vs. 2.12 ng/ml).
  • No significant gender difference in leptin concentration was observed.

Conclusions:

  • Established age-specific leptin reference ranges for infants up to 18 months.
  • Confirmed higher leptin in breast-fed infants during early infancy, a difference diminishing later.
  • Highlighted the importance of feeding type on infant leptin levels.