Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.9K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.9K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

891
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
891
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

650
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
650
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

2.1K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.1K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

7.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
7.3K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.7K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel transcatheter aortic valve replacement devices.

JTCVS structural and endovascular·2026
Same author

Long-term results of thumb carpometacarpal joint arthrodesis.

Archives of orthopaedic and trauma surgery·2026
Same author

Factors associated with variation in treatment of the distal radioulnar joint after plate fixation of distal radial fractures.

The Journal of hand surgery, European volume·2026
Same author

Restoration of CPAK type in total knee arthroplasty does not lead to superior clinical outcome: A study based on arthroplasty registry data.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Combined trochleoplasty and medial patellofemoral ligament reconstruction reduces patellar height.

Journal of experimental orthopaedics·2026
Same author

No significant side-to-side differences in retropatellar load distribution using more than 7.5 years after isolated MPFL reconstruction: A CT-osteoabsorptiometry pilot study in nine patients.

Journal of experimental orthopaedics·2026

Related Experiment Video

Updated: Apr 20, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

5.0K

Hypertriglyceridemia and Cardiovascular Outcomes.

Gurveen Malhotra1, Ankur Sethi, Rohit Arora

  • 11Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL; 2Department of Cardiology, Mount Sinai Hospital, Chicago, IL; and 3Department of Medicine, James Lovell Federal Health Care Center, North Chicago, IL.

American Journal of Therapeutics
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

Triglycerides (TG) are a controversial risk factor for cardiovascular disease. Recent research suggests elevated TG may increase cardiovascular mortality, especially in individuals with low low-density lipoprotein.

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K

Related Experiment Videos

Last Updated: Apr 20, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

5.0K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K

Area of Science:

  • Cardiology
  • Metabolic Disorders

Background:

  • Cardiovascular disease, especially ischemic heart disease, is a leading cause of death in the US.
  • Atherosclerosis, driven by risk factors like high LDL and hypertension, underlies ischemic heart disease.
  • The role of triglycerides (TG) in cardiovascular disease remains debated despite decades of research.

Purpose of the Study:

  • To review the current understanding of triglycerides as a cardiovascular risk factor.
  • To explore the significance of elevated TG in patients with low LDL.
  • To discuss potential interventions targeting TG for cardiovascular risk reduction.

Main Methods:

  • Literature review of studies investigating the relationship between TG and cardiovascular outcomes.
  • Analysis of recent meta-analyses on TG and cardiovascular mortality.
  • Examination of research on TG-lowering interventions.

Main Results:

  • Conflicting findings exist regarding the association between TG and cardiovascular mortality.
  • Recent meta-analyses indicate a significant positive relationship between TG and cardiovascular risk.
  • The impact of TG on cardiovascular health in specific patient populations (e.g., low LDL) requires further investigation.

Conclusions:

  • Triglycerides remain a controversial yet potentially significant risk factor for cardiovascular disease.
  • Further research is needed to clarify the role of TG and optimize therapeutic strategies.
  • Targeting TG may be a viable approach to reduce cardiovascular morbidity and mortality in select patients.