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Invasive Bordetella holmesii infections
Joel T Fishbain1, Kathleen Riederer, Hadi Sawaf
1From the Division of Infectious Diseases.
Infectious Diseases (London, England)
|November 22, 2014
Summary
Bordetella holmesii is a rare cause of invasive disease. Rapid identification of this challenging pathogen was achieved using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS).
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Bordetella holmesii is an uncommon pathogen causing invasive human infections.
- Standard microbiological techniques often struggle with the isolation and identification of B. holmesii due to its fastidious nature.
Observation:
- Two cases of B. holmesii bacteremia are presented.
- Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) enabled rapid and accurate speciation when conventional methods failed.
Findings:
- MALDI-TOF MS offers a significant advantage in the timely identification of B. holmesii bacteremia.
- Current guidelines for susceptibility testing and treatment of B. holmesii infections are lacking.
Implications:
- This study highlights the utility of MALDI-TOF MS for diagnosing rare bacterial infections.
- A comprehensive review of B. holmesii epidemiology, clinical features, and treatment is warranted to guide clinical practice.
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