Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K
Cancer Therapies02:49

Cancer Therapies

10.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.9K
Cancer Therapies02:49

Cancer Therapies

3.0K
3.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Radiation Oncology Department Open House Improves Medical Students' Reported Familiarity With and Interest in the Specialty.

Cureus·2026
Same author

Innovative Targets, New Technologies, Same Tenacity: Radiation Therapy's Evolving Role in Pancreatic Cancer.

International journal of radiation oncology, biology, physics·2026
Same author

Gaining New Ground: The Evolving Role of Radiation Therapy in Esophageal Cancer.

International journal of radiation oncology, biology, physics·2026
Same author

Radiation Therapy for Nonmalignant Diseases: An ASTRO-ESTRO-DEGRO-RANZCR Framework.

International journal of radiation oncology, biology, physics·2025
Same author

ASTRO Then and Now: Fifty Years of Evolving Science.

International journal of radiation oncology, biology, physics·2025
Same author

Impact on outcomes of ultra hypofractionation or hypofractionation regimens and proton or Xrays therapy in a phase III randomized controlled trial MC1635.

Frontiers in oncology·2025
Same journal

Present and Emerging Strategies for Disease Assessment in Hodgkin Lymphoma.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Nodular Lymphocyte-predominant Hodgkin Lymphoma: Incidence, Pathogenesis, Management.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Management of Classic Hodgkin Lymphoma in Special Clinical Situations.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Older Patients With Hodgkin Lymphoma: A Contemporary Review.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Adolescent and Young Adult Patients With Classical Hodgkin Lymphoma: A Review as a Case Study in AYA Cancer Care.

Cancer journal (Sudbury, Mass.)·2026
Same journal

Hodgkin Lymphoma: Management of Patients Who Fail Primary Therapy.

Cancer journal (Sudbury, Mass.)·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Proton therapy for sarcomas.

Sameer Keole1, Jonathan B Ashman, Thomas B Daniels

  • 1From the Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ.

Cancer Journal (Sudbury, Mass.)
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

Proton beam therapy offers a dosimetric advantage over advanced x-ray techniques for sarcoma treatment. This approach may improve outcomes by increasing radiation dose to tumors or reducing damage to healthy tissues.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.4K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K

Related Experiment Videos

Last Updated: Apr 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.4K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Sarcomas are diverse tumors affecting various sites and ages.
  • Conventional radiation therapy (x-ray) can cause significant dose to surrounding healthy tissues.
  • Proton beam therapy (PBT) is an advanced radiation technique.

Purpose of the Study:

  • To review dosimetric studies and clinical outcomes of PBT for sarcoma treatment.
  • To evaluate the potential of PBT to improve the therapeutic ratio in sarcoma management.

Main Methods:

  • Review of published dosimetric studies comparing PBT and advanced x-ray techniques.
  • Analysis of clinical outcome data from studies investigating PBT for sarcomas.
  • Assessment of dose reduction to non-target tissues with PBT.

Main Results:

  • PBT demonstrates a significant dosimetric advantage by lowering radiation dose to non-target tissues compared to x-ray therapy.
  • This dose reduction has the potential to improve treatment outcomes.
  • Studies suggest PBT may enhance local control or decrease normal tissue complications.

Conclusions:

  • Proton beam therapy shows promise for improving sarcoma treatment through its dosimetric benefits.
  • Further research and clinical data are crucial to fully establish the role of PBT in sarcoma management.